Assay Detail
Binding
CHEMBL4673766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-pentazocine from guinea pig brain sigma 1 receptor incubated for 120 mins by liquid scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and sigma receptor affinity of spiro[[2]benzopyran-1,1-cyclohexanes] with an exocyclic amino moiety in the 3-position
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.52 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100116 | PENTAZOCINE | 4.0 | 1 | 8.27 |
| CHEMBL4761627 | — | — | 1 | 8.27 |
| CHEMBL4792455 | — | — | 1 | 7.82 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.15 |
| CHEMBL4797610 | — | — | 1 | 7.02 |
| CHEMBL4781486 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100116 | PENTAZOCINE | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL4761627 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL4792455 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL4797610 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL4781486 | — | Ki | = | 278.0 | nM | 6.56 |