Assay Detail
Binding
CHEMBL4673767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DTG from Sprague-Dawley rat liver sigma 2 receptor incubated for 120 mins by liquid scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma intracellular receptor 2 (CHEMBL4105864) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and sigma receptor affinity of spiro[[2]benzopyran-1,1-cyclohexanes] with an exocyclic amino moiety in the 3-position
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.99 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.27 |
| CHEMBL4761627 | — | — | 1 | 7.22 |
| CHEMBL138083 | — | — | 1 | 7.00 |
| CHEMBL4797610 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL4761627 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL138083 | — | Ki | = | 99.7 | nM | 7.00 |
| CHEMBL4797610 | — | Ki | = | 340.0 | nM | 6.47 |