Assay Detail
Binding
CHEMBL4673829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at TLR7 in human PBMC assessed as induction of IN-12 stimulation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.97 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210884 | — | — | 1 | 6.03 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 5.90 |
| CHEMBL4763327 | — | — | 1 | - |
| CHEMBL1282 | IMIQUIMOD | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210884 | — | EC50 | = | 944.0 | nM | 6.03 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 1259.0 | nM | 5.90 |
| CHEMBL4763327 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1282 | IMIQUIMOD | EC50 | - | — | - |