Assay Detail
Binding
CHEMBL4675240
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Inhibition of human CYP1A1 expressed in HEK293 cells assessed as reduction in CYP1A1 mediated B[alpha]P-7,8- dihydrodiol induced-toxicity by measuring EC50 at 3 times of IC50 concentration by MTT assay (Rvb = 1.4 +/ 0.4 uM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.89 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458131 | PONGAMOL | — | 1 | 4.99 |
| CHEMBL224157 | LANCEOLATIN B | — | 1 | 4.84 |
| CHEMBL577397 | PONGAPIN | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458131 | PONGAMOL | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL224157 | LANCEOLATIN B | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL577397 | PONGAPIN | EC50 | = | 14800.0 | nM | 4.83 |