Assay Detail
ADMET
CHEMBL4675253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP1B1 expressed in sacchrosomes using 7-ethoxyresorufin as substrate by fluorescence based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.90 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.40 |
| CHEMBL224157 | LANCEOLATIN B | — | 1 | 6.54 |
| CHEMBL573847 | OVALITENONE | — | 1 | 6.22 |
| CHEMBL577397 | PONGAPIN | — | 1 | 6.02 |
| CHEMBL583961 | PONGAGLABRONE | — | 1 | 5.47 |
| CHEMBL4763663 | — | — | 1 | 5.42 |
| CHEMBL458131 | PONGAMOL | — | 1 | 5.41 |
| CHEMBL208484 | KARANJIN | — | 1 | 5.39 |
| CHEMBL4793151 | — | — | 1 | 5.21 |
| CHEMBL4740121 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL224157 | LANCEOLATIN B | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL573847 | OVALITENONE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL577397 | PONGAPIN | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL583961 | PONGAGLABRONE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4763663 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL458131 | PONGAMOL | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL208484 | KARANJIN | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4793151 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4740121 | — | IC50 | > | 20000.0 | nM | - |