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Assay Detail

CHEMBL4675514

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against nano-luciferase-expressing Cryptosporidium parvum infected in human HCT8 cells incubated for 72 hrs by luciferase reporter gene assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cryptosporidium parvum
Confidence 1 — Organism
Curated By Autocuration

Target

Cryptosporidium parvum (CHEMBL612855)
Type ORGANISM
Organism Cryptosporidium parvum

Publication

Development of 5-Aminopyrazole-4-carboxamide-based Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.
Huang W,Hulverson MA,Choi R,Arnold SLM,Zhang Z,McCloskey MC,Whitman GR,Hackman RC,Rivas KL,Barrett LK,Ojo KK,Van Voorhis WC,Fan E
J Med Chem (2019) 62 : 3135 -3146
PubMed 30830766 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 27 6.20 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4787093 1 6.68
CHEMBL4742781 1 6.60
CHEMBL4791496 1 6.46
CHEMBL4787718 1 6.43
CHEMBL4751724 1 6.39
CHEMBL4764836 1 6.38
CHEMBL4796309 1 6.37
CHEMBL4756756 1 6.36
CHEMBL4751897 1 6.35
CHEMBL4750746 1 6.31
CHEMBL4743192 1 6.29
CHEMBL4759936 1 6.28
CHEMBL4756763 1 6.22
CHEMBL4744995 1 6.19
CHEMBL4750862 1 6.18
CHEMBL3769570 1 6.15
CHEMBL4800671 1 6.15
CHEMBL4753185 1 6.15
CHEMBL4749451 1 6.14
CHEMBL4762379 1 6.13
CHEMBL4753941 1 6.06
CHEMBL3770980 1 6.05
CHEMBL4740515 1 5.99
CHEMBL4756120 1 5.91
CHEMBL4777462 1 5.88
CHEMBL3770743 1 5.74
CHEMBL4750009 1 5.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4787093 EC50 = 210.0 nM 6.68
CHEMBL4742781 EC50 = 250.0 nM 6.60
CHEMBL4791496 EC50 = 350.0 nM 6.46
CHEMBL4787718 EC50 = 370.0 nM 6.43
CHEMBL4751724 EC50 = 410.0 nM 6.39
CHEMBL4764836 EC50 = 420.0 nM 6.38
CHEMBL4796309 EC50 = 430.0 nM 6.37
CHEMBL4756756 EC50 = 440.0 nM 6.36
CHEMBL4751897 EC50 = 450.0 nM 6.35
CHEMBL4750746 EC50 = 490.0 nM 6.31
CHEMBL4743192 EC50 = 510.0 nM 6.29
CHEMBL4759936 EC50 = 530.0 nM 6.28
CHEMBL4756763 EC50 = 600.0 nM 6.22
CHEMBL4744995 EC50 = 650.0 nM 6.19
CHEMBL4750862 EC50 = 660.0 nM 6.18
CHEMBL3769570 EC50 = 710.0 nM 6.15
CHEMBL4800671 EC50 = 710.0 nM 6.15
CHEMBL4753185 EC50 = 710.0 nM 6.15
CHEMBL4749451 EC50 = 730.0 nM 6.14
CHEMBL4762379 EC50 = 740.0 nM 6.13
CHEMBL4753941 EC50 = 880.0 nM 6.06
CHEMBL3770980 EC50 = 890.0 nM 6.05
CHEMBL4740515 EC50 = 1030.0 nM 5.99
CHEMBL4756120 EC50 = 1220.0 nM 5.91
CHEMBL4777462 EC50 = 1320.0 nM 5.88
CHEMBL3770743 EC50 = 1820.0 nM 5.74
CHEMBL4750009 EC50 = 3300.0 nM 5.48