Assay Detail

CHEMBL4675936

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Functional

Inhibition of dog neutrophil cell migration

ChEMBL ↗

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Target

Neutrophil (CHEMBL613710) ↗

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Primary target Neutrophil

CHEMBL613710

Anchored from Assay target.

Protein identity Neutrophil

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Canis lupus familiaris
Cell Type	Neutrophil
Confidence	1 — Organism
Curated By	Autocuration

Target

Neutrophil (CHEMBL613710) ↗

Type

CELL-LINE

Publication

Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.

Labéguère F,Dupont S,Alvey L,Soulas F,Newsome G,Tirera A,Quenehen V,Mai TTT,Deprez P,Blanqué R,Oste L,Le Tallec S,De Vos S,Hagers A,Vandevelde A,Nelles L,Vandervoort N,Conrath K,Christophe T,van der Aar E,Wakselman E,Merciris D,Cottereaux C,da Costa C,Saniere L,Clement-Lacroix P,Jenkins L,Milligan G,Fletcher S,Brys R,Gosmini R
J Med Chem (2020) 63 : 13526 -13545
PubMed 32902984 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.04	7.12

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3716365	GLPG-1205	2.0	1	7.12
CHEMBL3717363	—	—	1	6.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3716365	GLPG-1205	IC50	=	75.0	nM	7.12
CHEMBL3717363	—	IC50	=	111.0	nM	6.96