Assay Detail
Functional
CHEMBL4676307
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Antibacterial activity against Escherichia coli assessed as reduction in bacterial growth measured for 12 day serial passage incubated for 24 hrs by serial dilution method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.70 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798191 | — | — | 1 | 4.70 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 4.70 |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798191 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL572 | NITROFURANTOIN | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL244888 | NIFUROXAZIDE | EC50 | = | 20000.0 | nM | 4.70 |