Assay Detail
Functional
CHEMBL4676312
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Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth by serial dilution method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus aureus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.96 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798191 | — | — | 1 | 5.52 |
| CHEMBL4172085 | — | — | 1 | 5.15 |
| CHEMBL479593 | — | — | 1 | 5.09 |
| CHEMBL1454910 | NITROXOLINE | 4.0 | 1 | 5.02 |
| CHEMBL1971965 | — | — | 1 | 5.02 |
| CHEMBL472882 | — | — | 1 | 5.00 |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | 4.80 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 4.57 |
| CHEMBL521258 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798191 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4172085 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL479593 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1454910 | NITROXOLINE | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1971965 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL472882 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL244888 | NIFUROXAZIDE | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL572 | NITROFURANTOIN | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL521258 | — | EC50 | = | 34000.0 | nM | 4.47 |