Assay Detail
Binding
CHEMBL4676318
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli GroEL/ES-mediated refolding of the denatured malate dehydrogenase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.27 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521258 | — | — | 1 | 4.58 |
| CHEMBL479593 | — | — | 1 | 4.16 |
| CHEMBL4798191 | — | — | 1 | 4.06 |
| CHEMBL1971965 | — | — | 1 | - |
| CHEMBL472882 | — | — | 1 | - |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | - |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | - |
| CHEMBL4172085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521258 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL479593 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL4798191 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL1971965 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL472882 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244888 | NIFUROXAZIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL572 | NITROFURANTOIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4172085 | — | IC50 | > | 100000.0 | nM | - |