Assay Detail
Binding
CHEMBL4676319
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Inhibition of Escherichia coli GroEL/ES-mediated refolding of the denatured malate dehydrogenase in presence of Escherichia coli type 1 NfsB nitroreductase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.86 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798191 | — | — | 1 | 5.50 |
| CHEMBL4172085 | — | — | 1 | 5.11 |
| CHEMBL479593 | — | — | 1 | 5.00 |
| CHEMBL521258 | — | — | 1 | 4.92 |
| CHEMBL472882 | — | — | 1 | 4.92 |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | 4.72 |
| CHEMBL1971965 | — | — | 1 | 4.64 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798191 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4172085 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL479593 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL521258 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL472882 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL244888 | NIFUROXAZIDE | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1971965 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 84000.0 | nM | 4.08 |