Assay Detail
Binding
CHEMBL4676328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-di-o-tolylguanidine from Sigma 2 receptor in rat liver membrane incubated for 120 mins by solid scintillation counting method
14
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma intracellular receptor 2 (CHEMBL4105864) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Fluorinated 2-Arylcyclopropan-1-amines - A new class of sigma receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.73 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741170 | — | — | 2 | 7.02 |
| CHEMBL1196613 | — | — | 2 | 5.92 |
| CHEMBL1190691 | — | — | 1 | 5.70 |
| CHEMBL4754599 | — | — | 2 | 5.64 |
| CHEMBL561746 | — | — | 1 | 5.51 |
| CHEMBL4758101 | — | — | 1 | 5.51 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 5.21 |
| CHEMBL4741351 | — | — | 2 | - |
| CHEMBL4756207 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741170 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL4741170 | — | Ki | = | 911.0 | nM | 6.04 |
| CHEMBL1196613 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1190691 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4754599 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL1196613 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL561746 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL4758101 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL3989843 | TRANYLCYPROMINE | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL4754599 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL4741351 | — | Ki | - | — | - | |
| CHEMBL4741351 | — | Ki | - | — | - | |
| CHEMBL4756207 | — | Ki | - | — | - | |
| CHEMBL4756207 | — | Ki | - | — | - |