Assay Detail
Binding
CHEMBL4676504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human coagulation factor alpha-thrombin using Boc-Val-Pro-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assay
36
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.32 | 8.19 |
| Ki | 1 | 8.35 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48361 | DABIGATRAN | 3.0 | 2 | 8.35 |
| CHEMBL4754247 | — | — | 1 | 7.57 |
| CHEMBL4777212 | — | — | 1 | 7.24 |
| CHEMBL4783236 | — | — | 1 | 7.07 |
| CHEMBL4748137 | — | — | 1 | 6.63 |
| CHEMBL4781896 | — | — | 1 | 6.62 |
| CHEMBL4750895 | — | — | 1 | 6.51 |
| CHEMBL4786773 | — | — | 1 | 6.48 |
| CHEMBL4776259 | — | — | 1 | 6.43 |
| CHEMBL4760132 | — | — | 1 | 6.38 |
| CHEMBL4754712 | — | — | 1 | 6.32 |
| CHEMBL4749335 | — | — | 1 | 6.31 |
| CHEMBL4740475 | — | — | 1 | 6.29 |
| CHEMBL4797183 | — | — | 1 | 6.06 |
| CHEMBL4746556 | — | — | 1 | 6.02 |
| CHEMBL2151128 | — | — | 1 | 5.91 |
| CHEMBL4800646 | — | — | 1 | 5.81 |
| CHEMBL4764774 | — | — | 1 | 5.75 |
| CHEMBL4786270 | — | — | 1 | 5.74 |
| CHEMBL4749147 | — | — | 1 | 5.47 |
| CHEMBL4759962 | — | — | 1 | 5.34 |
| CHEMBL4780154 | — | — | 1 | 4.88 |
| CHEMBL432863 | — | — | 1 | - |
| CHEMBL295684 | — | — | 1 | - |
| CHEMBL4764057 | — | — | 1 | - |
| CHEMBL4791078 | — | — | 1 | - |
| CHEMBL1568624 | — | — | 1 | - |
| CHEMBL4756713 | — | — | 1 | - |
| CHEMBL4748586 | — | — | 1 | - |
| CHEMBL4755409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48361 | DABIGATRAN | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL48361 | DABIGATRAN | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4754247 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4777212 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4783236 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4748137 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL4781896 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL4750895 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4786773 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL4776259 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL4760132 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL4754712 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL4749335 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL4740475 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL4797183 | — | IC50 | = | 865.0 | nM | 6.06 |
| CHEMBL4746556 | — | IC50 | = | 962.0 | nM | 6.02 |
| CHEMBL2151128 | — | IC50 | = | 1235.0 | nM | 5.91 |
| CHEMBL4800646 | — | IC50 | = | 1562.0 | nM | 5.81 |
| CHEMBL4764774 | — | IC50 | = | 1768.0 | nM | 5.75 |
| CHEMBL4786270 | — | IC50 | = | 1819.0 | nM | 5.74 |
| CHEMBL4749147 | — | IC50 | = | 3392.0 | nM | 5.47 |
| CHEMBL4759962 | — | IC50 | = | 4572.0 | nM | 5.34 |
| CHEMBL4780154 | — | IC50 | = | 13020.0 | nM | 4.88 |
| CHEMBL4761623 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4744082 | — | IC50 | > | 132000.0 | nM | - |
| CHEMBL4800151 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4762106 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4753362 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4755409 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4748586 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4756713 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4764057 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL295684 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1568624 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL432863 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4791078 | — | IC50 | > | 5000.0 | nM | - |