Assay Detail
Functional
CHEMBL4677393
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Antiviral activity against HIV-1 NL4-3 infected in human MT-4 cells assessed as inhibition of viral replication by measuring inhibition of cell viability preincubated with cells for 15 mins followed by viral infection and measured after 4 days by MTS/PES assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.56 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747494 | — | — | 1 | 6.03 |
| CHEMBL4791666 | — | — | 1 | 5.96 |
| CHEMBL1819181 | CYCLOTRIAZADISULFONAMIDE HYDROCHLORIDE | — | 1 | 5.78 |
| CHEMBL4746252 | — | — | 1 | 5.66 |
| CHEMBL4786809 | — | — | 1 | 5.64 |
| CHEMBL4750983 | — | — | 1 | 5.62 |
| CHEMBL4748787 | — | — | 1 | 5.61 |
| CHEMBL4783761 | — | — | 1 | 5.57 |
| CHEMBL4758659 | — | — | 1 | 5.55 |
| CHEMBL4755141 | — | — | 1 | 5.47 |
| CHEMBL4782080 | — | — | 1 | 4.98 |
| CHEMBL4743003 | — | — | 1 | 4.90 |
| CHEMBL4783030 | — | — | 1 | - |
| CHEMBL4750160 | — | — | 1 | - |
| CHEMBL4785236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747494 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4791666 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1819181 | CYCLOTRIAZADISULFONAMIDE HYDROCHLORIDE | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4746252 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4786809 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4750983 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL4748787 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4783761 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4758659 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4755141 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4782080 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4743003 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL4783030 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4750160 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4785236 | — | IC50 | > | 50000.0 | nM | - |