Assay Detail
Binding
CHEMBL4677472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-prazosin from adrenergic alpha1 in rat cerebral cortex
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel antipsychotic trans-4-(2-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)ethyl)cyclohexan-1-amine derivatives targeting dopamine/serotonin receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.05 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4780335 | — | — | 1 | 7.29 |
| CHEMBL2028019 | CARIPRAZINE | 4.0 | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4780335 | — | Ki | = | 51.3 | nM | 7.29 |
| CHEMBL2028019 | CARIPRAZINE | Ki | = | 155.0 | nM | 6.81 |