Assay Detail
Binding
CHEMBL4677480
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Binding affinity to adrenergic alpha1 receptor (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel antipsychotic trans-4-(2-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)ethyl)cyclohexan-1-amine derivatives targeting dopamine/serotonin receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.19 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 9.15 |
| CHEMBL3187365 | ASENAPINE | 4.0 | 1 | 8.92 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 8.15 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 7.96 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.72 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3187365 | ASENAPINE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL716 | QUETIAPINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL715 | OLANZAPINE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 57.0 | nM | 7.24 |