Assay Detail
Binding
CHEMBL4677625
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NIK (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of quinoline derivatives, as NF-κB inducing kinase (NIK) inhibitors with anti-inflammatory effects in vitro, low toxicities against T cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.46 | 9.64 |
| IC50 | 1 | 7.68 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4211840 | — | — | 1 | 9.64 |
| CHEMBL4073390 | — | — | 1 | 9.40 |
| CHEMBL3692450 | — | — | 1 | 9.33 |
| CHEMBL4741330 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4211840 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4073390 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL3692450 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL4741330 | — | IC50 | = | 21.0 | nM | 7.68 |