Assay Detail
Functional
CHEMBL4679105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 infected in human MT4 cells by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.46 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4742369 | — | — | 1 | 8.18 |
| CHEMBL4798646 | — | — | 1 | 8.18 |
| CHEMBL4777060 | — | — | 1 | 8.08 |
| CHEMBL4787805 | — | — | 1 | 8.00 |
| CHEMBL4789641 | — | — | 1 | 7.96 |
| CHEMBL4757346 | — | — | 1 | 7.96 |
| CHEMBL4798095 | — | — | 1 | 7.77 |
| CHEMBL4778776 | — | — | 1 | 7.70 |
| CHEMBL4796197 | — | — | 1 | 7.68 |
| CHEMBL3259907 | BI-224436 | 1.0 | 1 | 7.66 |
| CHEMBL4741337 | — | — | 1 | 7.50 |
| CHEMBL4790071 | — | — | 1 | 7.46 |
| CHEMBL4793299 | — | — | 1 | 7.35 |
| CHEMBL4758161 | — | — | 1 | 7.21 |
| CHEMBL4754449 | — | — | 1 | 6.75 |
| CHEMBL4781525 | — | — | 1 | 6.72 |
| CHEMBL4754803 | — | — | 1 | 6.66 |
| CHEMBL4786494 | — | — | 1 | 6.46 |
| CHEMBL4785613 | — | — | 1 | 6.44 |
| CHEMBL4743299 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4742369 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4798646 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4777060 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4787805 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4789641 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4757346 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4798095 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4778776 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4796197 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3259907 | BI-224436 | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4741337 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4790071 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4793299 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4758161 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4754449 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4781525 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4754803 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4786494 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4785613 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4743299 | — | EC50 | > | 100.0 | nM | - |