Assay Detail
Binding
CHEMBL4679477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full-length N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged Cyclin-T1 (1 to 726 residues) expressed in baculovirus expression system using PEP as substrate incubated for 17 mins in presence of ATP by TR-FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclin-Dependent Kinase Inhibitors in Cancer Therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.67 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3958430 | — | — | 1 | 8.22 |
| CHEMBL4743130 | — | — | 1 | 8.21 |
| CHEMBL4787666 | — | — | 1 | 8.15 |
| CHEMBL4742853 | — | — | 1 | 8.15 |
| CHEMBL4797439 | — | — | 1 | 8.12 |
| CHEMBL4785428 | — | — | 1 | 7.63 |
| CHEMBL4796706 | — | — | 1 | 7.50 |
| CHEMBL4776293 | — | — | 1 | 7.33 |
| CHEMBL4796549 | — | — | 1 | 7.15 |
| CHEMBL4742131 | — | — | 1 | 7.09 |
| CHEMBL4759094 | — | — | 1 | 6.83 |
| CHEMBL4745518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3958430 | — | IC50 | = | 6.03 | nM | 8.22 |
| CHEMBL4743130 | — | IC50 | = | 6.18 | nM | 8.21 |
| CHEMBL4787666 | — | IC50 | = | 7.13 | nM | 8.15 |
| CHEMBL4742853 | — | IC50 | = | 7.08 | nM | 8.15 |
| CHEMBL4797439 | — | IC50 | = | 7.55 | nM | 8.12 |
| CHEMBL4785428 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL4796706 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL4776293 | — | IC50 | = | 46.6 | nM | 7.33 |
| CHEMBL4796549 | — | IC50 | = | 70.7 | nM | 7.15 |
| CHEMBL4742131 | — | IC50 | = | 80.5 | nM | 7.09 |
| CHEMBL4759094 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4745518 | — | IC50 | < | 3.2 | nM | - |