Assay Detail
Functional
CHEMBL4680485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 blood stream forms after 72 hrs by resazurin dye based fluorescence assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 6.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.70 |
| CHEMBL4786814 | — | — | 1 | 8.20 |
| CHEMBL4753757 | — | — | 1 | 8.10 |
| CHEMBL4764546 | — | — | 1 | 8.10 |
| CHEMBL4750442 | — | — | 1 | 7.80 |
| CHEMBL4758874 | — | — | 1 | 7.70 |
| CHEMBL4776376 | — | — | 1 | 7.70 |
| CHEMBL4740571 | — | — | 1 | 7.40 |
| CHEMBL4799228 | — | — | 1 | 6.80 |
| CHEMBL4761576 | — | — | 1 | 6.80 |
| CHEMBL4796633 | — | — | 1 | 6.20 |
| CHEMBL4761919 | — | — | 1 | 6.10 |
| CHEMBL4762633 | — | — | 1 | 6.10 |
| CHEMBL4790031 | — | — | 1 | 6.10 |
| CHEMBL4790499 | — | — | 1 | 5.90 |
| CHEMBL4791712 | — | — | 1 | 5.90 |
| CHEMBL4795660 | — | — | 1 | 5.80 |
| CHEMBL4780547 | — | — | 1 | 5.80 |
| CHEMBL4756094 | — | — | 1 | 5.80 |
| CHEMBL4762558 | — | — | 1 | 5.70 |
| CHEMBL4761457 | — | — | 1 | 5.60 |
| CHEMBL4787851 | — | — | 1 | 5.20 |
| CHEMBL4742777 | — | — | 1 | 5.20 |
| CHEMBL4743077 | — | — | 1 | 5.00 |
| CHEMBL3290295 | — | — | 1 | 5.00 |
| CHEMBL4764775 | — | — | 1 | 4.90 |
| CHEMBL4753533 | — | — | 1 | 4.90 |
| CHEMBL4795669 | — | — | 1 | 4.60 |
| CHEMBL4782388 | — | — | 1 | - |
| CHEMBL4787117 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4786814 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4753757 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4764546 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4750442 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL4758874 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4776376 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4740571 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4799228 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4761576 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4796633 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4761919 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4762633 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4790031 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4790499 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4791712 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4795660 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4780547 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4756094 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4762558 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4761457 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4787851 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4742777 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4743077 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3290295 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4764775 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4753533 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4795669 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4782388 | — | EC50 | > | 39810.72 | nM | - |
| CHEMBL4787117 | — | EC50 | < | 1.995 | nM | - |