Assay Detail
Functional
CHEMBL4680702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Z138 cells incubated for 5 days by cell titer-glo assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Z-138 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.94 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4542380 | — | — | 1 | 7.21 |
| CHEMBL4060831 | — | — | 1 | 6.46 |
| CHEMBL3938760 | — | — | 1 | 6.42 |
| CHEMBL3919677 | — | — | 1 | 6.37 |
| CHEMBL3958947 | — | — | 1 | 6.35 |
| CHEMBL3963350 | — | — | 1 | 6.05 |
| CHEMBL3927051 | — | — | 1 | 5.78 |
| CHEMBL3913586 | — | — | 1 | 5.68 |
| CHEMBL3977219 | — | — | 1 | 5.37 |
| CHEMBL3962874 | — | — | 1 | 4.90 |
| CHEMBL3914119 | — | — | 1 | 4.73 |
| CHEMBL3890510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4542380 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4060831 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL3938760 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL3919677 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL3958947 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL3963350 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3927051 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL3913586 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3977219 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL3962874 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3914119 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL3890510 | — | IC50 | - | — | - |