Compound Detail
CHEMBL4542380
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Basic Information
| ChEMBL ID | CHEMBL4542380 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TWKYXZSXXXKKJU-FQEVSTJZSA-N |
5
Targets
60
Activities
3
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
380.5
MW (Da)
2.19
ALogP
5
HBA
3
HBD
77.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 44 meas. best 8.52
EC50 11 meas. best 8.68
Ki 5 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 5 CHEMBL1795116 | EC50 | 8.68 | 7.965 | 2.1 | 2 |
| PRMT5/MEP50 complex CHEMBL3137261 | Ki | 8.62 | 8.204 | 2.4 | 5 |
| Protein arginine N-methyltransferase 5 CHEMBL1795116 | IC50 | 8.52 | 8.1386 | 3.0 | 7 |
| PRMT5/MEP50 complex CHEMBL3137261 | IC50 | 8.4 | 8.0383 | 4.0 | 6 |
| Unchecked CHEMBL612545 | EC50 | 8.15 | 6.705 | 7.0 | 8 |
| Unchecked CHEMBL612545 | IC50 | 7.3 | 5.9004 | 50.0 | 26 |
| Z-138 CHEMBL4483276 | IC50 | 7.21 | 7.21 | 62.0 | 1 |
| G411 CHEMBL6066763 | EC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine