Assay Detail
Functional
CHEMBL4681665
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Antiviral activity against HBV infected in human HepG2 assessed as reduction in viral replication incubated for 6 days by real time Q-PCR analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Next-Generation Reduction Sensitive Lipid Conjugates of Tenofovir: Antiviral Activity and Mechanism of Release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.19 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4597650 | — | — | 1 | 7.70 |
| CHEMBL4791164 | — | — | 1 | 6.82 |
| CHEMBL4761153 | — | — | 1 | 6.61 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 6.47 |
| CHEMBL4791476 | — | — | 1 | 5.98 |
| CHEMBL4755064 | — | — | 1 | 5.35 |
| CHEMBL4557355 | — | — | 1 | 4.38 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | - |
| CHEMBL4760679 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4597650 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4791164 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4761153 | — | EC50 | = | 248.0 | nM | 6.61 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4791476 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4755064 | — | EC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL4557355 | — | EC50 | = | 41900.0 | nM | 4.38 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | - | — | - | |
| CHEMBL4760679 | — | EC50 | > | 100000.0 | nM | - |