Assay Detail
Binding
CHEMBL4682230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human Vps34 expressed in mammalian expression system
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase catalytic subunit type 3 (CHEMBL1075165) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.54 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2140173 | — | — | 1 | 8.77 |
| CHEMBL4794132 | — | — | 1 | 8.70 |
| CHEMBL4752634 | — | — | 1 | 8.40 |
| CHEMBL4792737 | — | — | 1 | 8.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2140173 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL4794132 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL4752634 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL4792737 | — | Kd | = | 5.1 | nM | 8.29 |