Assay Detail
Binding
CHEMBL4682233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full-length human VPS34 incubated for 60 mins by ADP-Glo kinase assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase catalytic subunit type 3 (CHEMBL1075165) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.58 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745255 | — | — | 1 | 7.85 |
| CHEMBL2140173 | — | — | 1 | 7.77 |
| CHEMBL4760480 | — | — | 1 | 7.70 |
| CHEMBL4794132 | — | — | 1 | 7.62 |
| CHEMBL4792737 | — | — | 1 | 7.54 |
| CHEMBL4752634 | — | — | 1 | 7.39 |
| CHEMBL4783168 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745255 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2140173 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4760480 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4794132 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4792737 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4752634 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4783168 | — | IC50 | = | 67.0 | nM | 7.17 |