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Assay Detail

CHEMBL4682403

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
ChEMBL ↗
56
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type WI-38
Confidence 1 — Organism
Curated By Autocuration

Target

WI-38 (CHEMBL614391) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis.
Ayoup MS,Fouad MA,Abdel-Hamid H,Ramadan ES,Abu-Serie MM,Noby A,Teleb M
Eur J Med Chem (2020) 186 : 111875 -111875
PubMed 31740054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 6.66 7.58
EC100 28 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 2 7.58
CHEMBL4790818 — — 2 7.54
CHEMBL4757130 — — 2 7.54
CHEMBL4792262 — — 2 7.46
CHEMBL4796100 — — 2 7.37
CHEMBL4752138 — — 2 7.37
CHEMBL4751325 — — 2 7.34
CHEMBL4740677 — — 2 6.84
CHEMBL4747966 — — 2 6.74
CHEMBL4780272 — — 2 6.71
CHEMBL4789506 — — 2 6.70
CHEMBL4788977 — — 2 6.68
CHEMBL4740010 — — 2 6.66
CHEMBL4782405 — — 2 6.63
CHEMBL4762356 — — 2 6.58
CHEMBL4780030 — — 2 6.50
CHEMBL4745841 — — 2 6.50
CHEMBL4764578 — — 2 6.46
CHEMBL4751463 — — 2 6.44
CHEMBL4788683 — — 2 6.43
CHEMBL4759262 — — 2 6.38
CHEMBL4761287 — — 2 6.30
CHEMBL4792674 — — 2 6.29
CHEMBL4755594 — — 2 6.26
CHEMBL4782980 — — 2 6.09
CHEMBL4764093 — — 2 5.92
CHEMBL4740396 — — 2 5.83
CHEMBL4783901 — — 2 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 26.6 nM 7.58
CHEMBL4790818 — IC50 = 29.1 nM 7.54
CHEMBL4757130 — IC50 = 28.6 nM 7.54
CHEMBL4792262 — IC50 = 35.1 nM 7.46
CHEMBL4752138 — IC50 = 42.9 nM 7.37
CHEMBL4796100 — IC50 = 42.7 nM 7.37
CHEMBL4751325 — IC50 = 46.0 nM 7.34
CHEMBL4740677 — IC50 = 143.4 nM 6.84
CHEMBL4747966 — IC50 = 182.4 nM 6.74
CHEMBL4780272 — IC50 = 195.0 nM 6.71
CHEMBL4789506 — IC50 = 198.7 nM 6.70
CHEMBL4788977 — IC50 = 210.4 nM 6.68
CHEMBL4740010 — IC50 = 218.5 nM 6.66
CHEMBL4782405 — IC50 = 233.2 nM 6.63
CHEMBL4762356 — IC50 = 260.4 nM 6.58
CHEMBL4745841 — IC50 = 318.4 nM 6.50
CHEMBL4780030 — IC50 = 314.0 nM 6.50
CHEMBL4764578 — IC50 = 348.0 nM 6.46
CHEMBL4751463 — IC50 = 359.8 nM 6.44
CHEMBL4788683 — IC50 = 374.0 nM 6.43
CHEMBL4759262 — IC50 = 422.0 nM 6.38
CHEMBL4761287 — IC50 = 498.9 nM 6.30
CHEMBL4792674 — IC50 = 509.0 nM 6.29
CHEMBL4755594 — IC50 = 542.8 nM 6.26
CHEMBL4782980 — IC50 = 819.0 nM 6.09
CHEMBL4764093 — IC50 = 1201.0 nM 5.92
CHEMBL4740396 — IC50 = 1462.0 nM 5.83
CHEMBL4783901 — IC50 = 4564.0 nM 5.34
CHEMBL4788683 — EC100 = 107.4 nM -
CHEMBL4751463 — EC100 = 198.9 nM -
CHEMBL4782405 — EC100 = 12.7 nM -
CHEMBL4745841 — EC100 = 188.3 nM -
CHEMBL4789506 — EC100 = 89.7 nM -
CHEMBL4757130 — EC100 = 14.9 nM -
CHEMBL4747966 — EC100 = 113.6 nM -
CHEMBL4761287 — EC100 = 305.4 nM -
CHEMBL4796100 — EC100 = 18.25 nM -
CHEMBL4762356 — EC100 = 36.1 nM -
CHEMBL4755594 — EC100 = 161.5 nM -
CHEMBL4792674 — EC100 = 301.0 nM -
CHEMBL4783901 — EC100 = 1912.0 nM -
CHEMBL4740396 — EC100 = 540.3 nM -
CHEMBL4764578 — EC100 = 112.4 nM -
CHEMBL4790818 — EC100 = 4.8 nM -
CHEMBL4782980 — EC100 = 290.7 nM -
CHEMBL4780030 — EC100 = 93.5 nM -
CHEMBL4780272 — EC100 = 141.4 nM -
CHEMBL4752138 — EC100 = 18.2 nM -
CHEMBL4740010 — EC100 = 84.9 nM -
CHEMBL53463 DOXORUBICIN EC100 = 12.1 nM -