Assay Detail
Binding
CHEMBL4682412
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Inhibition of MMP-1 (unknown origin) by colorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.30 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311932 | — | — | 1 | 7.51 |
| CHEMBL4788683 | — | — | 1 | 7.39 |
| CHEMBL4780030 | — | — | 1 | 7.33 |
| CHEMBL4792262 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311932 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4788683 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4780030 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4792262 | — | IC50 | = | 104.0 | nM | 6.98 |