Assay Detail
Binding
CHEMBL4682414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase AKT (CHEMBL2111353) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.75 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792262 | — | — | 1 | 8.87 |
| CHEMBL4780030 | — | — | 1 | 8.68 |
| CHEMBL4788683 | — | — | 1 | 8.05 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792262 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL4780030 | — | IC50 | = | 2.11 | nM | 8.68 |
| CHEMBL4788683 | — | IC50 | = | 8.82 | nM | 8.05 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 4000.0 | nM | 5.40 |