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Target Snapshot

CHEMBL2111353 Target Snapshot

Serine/threonine-protein kinase AKT · PROTEIN FAMILY · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
192Compounds
161Assays
1Approved Drugs
175.0Activities
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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Serine/threonine-protein kinase AKT shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 9 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P31751. Start with neoplasm, then reuse UniProt P31751 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with neoplasm, then reuse UniProt P31751 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 9 linked drugs
Open source guide
Disease program
neoplasm

Serine/threonine-protein kinase AKT shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 9 linked drugs remain visible in the same block.

Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AFURESERTIB, CAPIVASERTIB, IPATASERTIB, MIRANSERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 9 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase AKT as ChEMBL target CHEMBL2111353, mapped to UniProt P31751. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase AKT
PROTEIN FAMILY · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2111353
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P31751
RAC-beta serine/threonine-protein kinase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase AKT is the right protein anchor across sources, using UniProt P31751 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 9 linked drugs in the same disease frame.

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Evidence Card
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Overview

Basic Information

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Preferred NameSerine/threonine-protein kinase AKT
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtP31751
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRAC-beta serine/threonine-protein kinase
UniProt AccessionP31751
Component TypeProtein
Sequence Length481 aa

RAC-beta serine/threonine-protein kinase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase AKT, mapped to UniProt P31751. ChEMBL maps the protein component as RAC-beta serine/threonine-protein kinase. Sequence length is 481 aa.

Mapped IDP31751
Review nameSerine/threonine-protein kinase AKT
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Serine/threonine-protein kinase AKT shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
neoplasm
9 linked drugs · 9 direct · 9 efficacy
Linked drugAFURESERTIB
Linked drugCAPIVASERTIB
Linked drugIPATASERTIB
Linked drugMIRANSERTIB
Approved-linked Approved
cancer
8 linked drugs · 8 direct · 8 efficacy
Linked drugAFURESERTIB
Linked drugCAPIVASERTIB
Linked drugGSK-690693
Linked drugIPATASERTIB
Approved-linked Approved
breast cancer
4 linked drugs · 4 direct · 4 efficacy
Linked drugAFURESERTIB
Linked drugCAPIVASERTIB
Linked drugIPATASERTIB
Linked drugMK-2206
Approved-linked Approved
breast neoplasm
2 linked drugs · 2 direct · 2 efficacy
Linked drugCAPIVASERTIB
Linked drugIPATASERTIB
Late clinical Phase III
triple-negative breast cancer
4 linked drugs · 4 direct · 4 efficacy
Linked drugCAPIVASERTIB
Linked drugIPATASERTIB
Linked drugMK-2206
Linked drugUPROSERTIB
Late clinical Phase III
prostate cancer
3 linked drugs · 3 direct · 3 efficacy
Linked drugAFURESERTIB
Linked drugCAPIVASERTIB
Linked drugIPATASERTIB
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AFURESERTIB, CAPIVASERTIB, IPATASERTIB, MIRANSERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseneoplasm
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50156.0
KI5.0
EC506.0
KD8.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4795065 9.7 IC50 0.2 Preclinical
CHEMBL5426352 9.52 IC50 0.3 Preclinical
CHEMBL5414256 9.05 IC50 0.9 Preclinical
CHEMBL3919089 9.0 IC50 1.0 Preclinical
CHEMBL5402470 9.0 IC50 1.0 Preclinical
CHEMBL5406950 9.0 IC50 1.0 Preclinical
CHEMBL4792262 8.87 IC50 1.34 Preclinical
CHEMBL4853207 8.85 IC50 1.4 Preclinical
CHEMBL5437679 8.7 IC50 2.0 Preclinical
CHEMBL4780030 8.68 IC50 2.11 Preclinical
Distribution

pChEMBL Value Distribution

25
5.0
18
5.5
16
6.0
14
6.5
8
7.0
12
7.5
13
8.0
12
8.5
4
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

CAPIVASERTIB
CHEMBL2325741
Approved 2023
Properties Compare Identifier
Assay Landscape

Assay Landscape

161
Total Assays
90
Tested Compounds
2
Assay Types
Binding — 149 assays, 90 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 123 38 6.4
protein format 26 52 6.8
Functional — 12 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 2 6.1
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine