Compound Detail
CHEMBL5406950
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Cc1cc([C@@H](C)Nc2ccccc2C(=O)O)c2nc(N3CCC(C)(C)CC3)c(C#N)c(=O)n2c1
Basic Information
| ChEMBL ID | CHEMBL5406950 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZOJLNHIFYZCUMX-QGZVFWFLSA-N |
2
Targets
3
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
459.6
MW (Da)
4.37
ALogP
7
HBA
2
HBD
110.7
PSA (Ų)
0.58
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase AKT CHEMBL2111353 | IC50 | 9.0 | 7.625 | 1.0 | 2 |
| T47D CHEMBL614361 | IC50 | 6.82 | 6.82 | 151.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 76.0 | mL.min-1.kg-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase AKT | IC50 | = | 1.0 | nM | 9.0 | Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R... | 38477582 |
| T47D | IC50 | = | 151.0 | nM | 6.82 | Cytotoxicity against human T47D cells harboring PI3Kalpha H1047R mutant assessed... | 38477582 |
| Serine/threonine-protein kinase AKT | IC50 | = | 567.0 | nM | 6.25 | Inhibition of AKT phosphorylation in human SK-BR-3 cells harboring wildtype PI3K... | 38477582 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38477582 | 10.1021/acs.jmedchem.4c00078 | Serine/threonine-protein kinase AKT | 2 |
| 38477582 | 10.1021/acs.jmedchem.4c00078 | T47D | 1 |
| 38477582 | 10.1021/acs.jmedchem.4c00078 | SK-BR-3 | 1 |
| 38477582 | 10.1021/acs.jmedchem.4c00078 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine