Assay Detail
Functional
CHEMBL5389547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human T47D cells harboring PI3Kalpha H1047R mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo 2.0 luminescent cell viability assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.55 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5402470 | — | — | 1 | 7.32 |
| CHEMBL5437679 | — | — | 1 | 7.25 |
| CHEMBL5424195 | — | — | 1 | 7.15 |
| CHEMBL5414256 | — | — | 1 | 7.07 |
| CHEMBL5423227 | — | — | 1 | 6.92 |
| CHEMBL5411976 | — | — | 1 | 6.87 |
| CHEMBL5406950 | — | — | 1 | 6.82 |
| CHEMBL5419204 | — | — | 1 | 6.80 |
| CHEMBL5406570 | — | — | 1 | 6.74 |
| CHEMBL5408522 | — | — | 1 | 6.61 |
| CHEMBL5430524 | — | — | 1 | 6.52 |
| CHEMBL5404456 | — | — | 1 | 6.31 |
| CHEMBL5424291 | — | — | 1 | 6.25 |
| CHEMBL5422741 | — | — | 1 | 6.20 |
| CHEMBL5436038 | — | — | 1 | 5.96 |
| CHEMBL5409207 | — | — | 1 | 5.43 |
| CHEMBL5440814 | — | — | 1 | 5.21 |
| CHEMBL5401780 | — | — | 1 | - |
| CHEMBL5413908 | — | — | 1 | - |
| CHEMBL5431134 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5402470 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5437679 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5424195 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5414256 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5423227 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5411976 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5406950 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5419204 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5406570 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5408522 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL5430524 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL5404456 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL5424291 | — | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL5422741 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL5436038 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5409207 | — | IC50 | = | 3725.0 | nM | 5.43 |
| CHEMBL5440814 | — | IC50 | = | 6239.0 | nM | 5.21 |
| CHEMBL5401780 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5413908 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5431134 | — | IC50 | > | 10000.0 | nM | - |