Assay Detail
Functional
CHEMBL4682690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 strain 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathogenicity by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.92 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.59 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.49 |
| CHEMBL4747887 | — | — | 1 | 8.19 |
| CHEMBL4760322 | — | — | 1 | 8.07 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.75 |
| CHEMBL4795358 | — | — | 1 | 7.51 |
| CHEMBL4749739 | — | — | 1 | 7.43 |
| CHEMBL4791463 | — | — | 1 | 7.11 |
| CHEMBL4753622 | — | — | 1 | 6.85 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.82 |
| CHEMBL4753117 | — | — | 1 | 6.68 |
| CHEMBL4759040 | — | — | 1 | 6.64 |
| CHEMBL4782911 | — | — | 1 | 6.60 |
| CHEMBL4750572 | — | — | 1 | 6.55 |
| CHEMBL4755739 | — | — | 1 | 6.52 |
| CHEMBL4789866 | — | — | 1 | 6.43 |
| CHEMBL4753696 | — | — | 1 | 6.41 |
| CHEMBL4795491 | — | — | 1 | 6.33 |
| CHEMBL4791987 | — | — | 1 | 6.26 |
| CHEMBL4748035 | — | — | 1 | 5.82 |
| CHEMBL4755133 | — | — | 1 | 5.64 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4747887 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4760322 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4795358 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4749739 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4791463 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4753622 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4753117 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4759040 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4782911 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4750572 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4755739 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4789866 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4753696 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4795491 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4791987 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4748035 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4755133 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 3100.0 | nM | 5.51 |