Assay Detail
Functional
CHEMBL4682691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 K103N mutant strain infected in human MT4 cells assessed as reduction in virus-induced cytopathogenicity by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 5.84 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.49 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.72 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.12 |
| CHEMBL4747887 | — | — | 1 | 7.11 |
| CHEMBL4760322 | — | — | 1 | 6.66 |
| CHEMBL4795358 | — | — | 1 | 5.72 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 5.70 |
| CHEMBL4791463 | — | — | 1 | 5.58 |
| CHEMBL4753622 | — | — | 1 | 5.42 |
| CHEMBL4759040 | — | — | 1 | 5.40 |
| CHEMBL4782911 | — | — | 1 | 5.31 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 5.25 |
| CHEMBL4753117 | — | — | 1 | 5.24 |
| CHEMBL4789866 | — | — | 1 | 5.09 |
| CHEMBL4755739 | — | — | 1 | 5.08 |
| CHEMBL4791987 | — | — | 1 | 5.05 |
| CHEMBL4753696 | — | — | 1 | 5.02 |
| CHEMBL4750572 | — | — | 1 | 5.01 |
| CHEMBL4795491 | — | — | 1 | 5.00 |
| CHEMBL4755133 | — | — | 1 | - |
| CHEMBL4748035 | — | — | 1 | - |
| CHEMBL4749739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4747887 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4760322 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4795358 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4791463 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4753622 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4759040 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4782911 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4753117 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4789866 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4755739 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4791987 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4753696 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4750572 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4795491 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4755133 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL4748035 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL4749739 | — | EC50 | > | 5400.0 | nM | - |