Assay Detail
Binding
CHEMBL4682742
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in presence of 100 uM of GTP by scintillation counting analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted 4-phenylthiazoles: Development of potent and selective A, A and dual A/A adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.00 | 10.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4797181 | — | — | 1 | 10.12 |
| CHEMBL4796077 | — | — | 1 | 10.08 |
| CHEMBL4764086 | — | — | 1 | 10.01 |
| CHEMBL4784975 | — | — | 1 | 8.50 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4797181 | — | IC50 | = | 0.0763 | nM | 10.12 |
| CHEMBL4796077 | — | IC50 | = | 0.084 | nM | 10.08 |
| CHEMBL4764086 | — | IC50 | = | 0.0981 | nM | 10.01 |
| CHEMBL4784975 | — | IC50 | = | 3.14 | nM | 8.50 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | IC50 | = | 537.6 | nM | 6.27 |