Assay Detail
Functional
CHEMBL4683032
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Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition after 72 hrs by trypan blue staining based cell counting assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.53 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749523 | — | — | 1 | 6.43 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.38 |
| CHEMBL4777978 | — | — | 1 | 6.14 |
| CHEMBL412101 | — | — | 1 | 5.87 |
| CHEMBL4764655 | — | — | 1 | 5.87 |
| CHEMBL4799339 | — | — | 1 | 5.85 |
| CHEMBL4764645 | — | — | 1 | 5.82 |
| CHEMBL4747283 | — | — | 1 | 5.79 |
| CHEMBL4798060 | — | — | 1 | 5.75 |
| CHEMBL4780648 | — | — | 1 | 5.68 |
| CHEMBL4756527 | — | — | 1 | 5.56 |
| CHEMBL4795469 | — | — | 1 | 5.55 |
| CHEMBL4798231 | — | — | 1 | 5.47 |
| CHEMBL4786061 | — | — | 1 | 5.36 |
| CHEMBL4798787 | — | — | 1 | 5.32 |
| CHEMBL4786803 | — | — | 1 | 5.06 |
| CHEMBL4787445 | — | — | 1 | 5.02 |
| CHEMBL4750111 | — | — | 1 | 4.81 |
| CHEMBL4779111 | — | — | 1 | 4.67 |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749523 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4777978 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL412101 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4764655 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4799339 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4764645 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4747283 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4798060 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4780648 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4756527 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4795469 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL4798231 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL4786061 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL4798787 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL4786803 | — | IC50 | = | 8780.0 | nM | 5.06 |
| CHEMBL4787445 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL4750111 | — | IC50 | = | 15450.0 | nM | 4.81 |
| CHEMBL4779111 | — | IC50 | = | 21610.0 | nM | 4.67 |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 55280.0 | nM | 4.26 |