Assay Detail
Functional
CHEMBL4683198
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Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.03 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798007 | — | — | 1 | 6.22 |
| CHEMBL4745909 | — | — | 1 | 6.10 |
| CHEMBL4798881 | — | — | 1 | 6.10 |
| CHEMBL4785329 | — | — | 1 | 6.05 |
| CHEMBL4791122 | — | — | 1 | 5.96 |
| CHEMBL4462238 | — | — | 1 | 5.92 |
| CHEMBL4748834 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798007 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4745909 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4798881 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4785329 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4791122 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4462238 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4748834 | — | IC50 | = | 1300.0 | nM | 5.89 |