Assay Detail
Binding
CHEMBL4683701
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Inhibition of jack bean alpha-mannosidase using PNPG as substrate incubated for 10 mins by spectrophotometric method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.45 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745549 | — | — | 1 | 4.85 |
| CHEMBL3407639 | — | — | 1 | 4.82 |
| CHEMBL454551 | L-RADICAMINE A | — | 1 | 4.55 |
| CHEMBL4783560 | — | — | 1 | 4.55 |
| CHEMBL4751456 | — | — | 1 | 4.55 |
| CHEMBL4796653 | — | — | 1 | 4.55 |
| CHEMBL4788384 | — | — | 1 | 4.55 |
| CHEMBL1765390 | (E)-BUTYLIDENEPHTHALIDE | — | 1 | 4.39 |
| CHEMBL4800248 | — | — | 1 | 4.38 |
| CHEMBL13311 | CHROMONE | — | 1 | 4.31 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.31 |
| CHEMBL1230107 | CASUARINE | — | 1 | 4.29 |
| CHEMBL4758678 | — | — | 1 | 4.21 |
| CHEMBL4750240 | — | — | 1 | 4.04 |
| CHEMBL199829 | — | — | 1 | - |
| CHEMBL371723 | — | — | 1 | - |
| CHEMBL199442 | — | — | 1 | - |
| CHEMBL382280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745549 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3407639 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL454551 | L-RADICAMINE A | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4783560 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4751456 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4796653 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4788384 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1765390 | (E)-BUTYLIDENEPHTHALIDE | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4800248 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL13311 | CHROMONE | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL44 | GENISTEIN | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1230107 | CASUARINE | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4758678 | — | IC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL4750240 | — | IC50 | = | 92300.0 | nM | 4.04 |
| CHEMBL199829 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL371723 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL199442 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL382280 | — | IC50 | = | 105000.0 | nM | - |