Compound Detail
CHEMBL454551
L-RADICAMINE A Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL454551 |
| Name | L-RADICAMINE A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NEAQPVOYHYPSER-BVALORAHSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
255.3
MW (Da)
-0.87
ALogP
6
HBA
5
HBD
102.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Maltase-glucoamylase CHEMBL2074 | IC50 | 5.17 | 5.17 | 6700.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.6 | 4.6 | 25210.0 | 1 |
| Alpha-mannosidase CHEMBL3392945 | IC50 | 4.55 | 4.55 | 28000.0 | 1 |
| Tissue alpha-L-fucosidase CHEMBL3545 | IC50 | 4.39 | 4.39 | 41000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Maltase-glucoamylase | IC50 | = | 6700.0 | nM | 5.17 | Inhibition of alpha-glucosidase (unknown origin) using sucrose as substrate incu... | 31927314 |
| Unchecked | IC50 | = | 25210.0 | nM | 4.6 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate... | 31927314 |
| Alpha-mannosidase | IC50 | = | 28000.0 | nM | 4.55 | Inhibition of jack bean alpha-mannosidase using PNPG as substrate incubated for ... | 31927314 |
| Tissue alpha-L-fucosidase | IC50 | = | 41000.0 | nM | 4.39 | Inhibition of bovine kidney alpha-fucosidase using PNPG as substrate incubated f... | 31927314 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19008111 | 10.1016/j.bmc.2008.10.063 | Unchecked | 4 |
| 31927314 | 10.1016/j.ejmech.2020.112034 | Maltase-glucoamylase | 1 |
| 31927314 | 10.1016/j.ejmech.2020.112034 | Unchecked | 1 |
| 31927314 | 10.1016/j.ejmech.2020.112034 | Tissue alpha-L-fucosidase | 1 |
| 31927314 | 10.1016/j.ejmech.2020.112034 | Alpha-mannosidase | 1 |
Data from ChEMBL 36 via Core Engine