Assay Detail
Binding
CHEMBL4683699
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Inhibition of bovine kidney alpha-fucosidase using PNPG as substrate incubated for 10 mins by spectrophotometric method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Kidney |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.32 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4748590 | — | — | 1 | 4.89 |
| CHEMBL4745549 | — | — | 1 | 4.68 |
| CHEMBL4757703 | — | — | 1 | 4.66 |
| CHEMBL4800248 | — | — | 1 | 4.52 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 4.50 |
| CHEMBL418068 | RHEIN | — | 1 | 4.50 |
| CHEMBL42624 | PHYSCION | — | 1 | 4.50 |
| CHEMBL289277 | EMODIN | — | 1 | 4.50 |
| CHEMBL4758678 | — | — | 1 | 4.42 |
| CHEMBL4783560 | — | — | 1 | 4.39 |
| CHEMBL454551 | L-RADICAMINE A | — | 1 | 4.39 |
| CHEMBL4750240 | — | — | 1 | 4.29 |
| CHEMBL13311 | CHROMONE | — | 1 | 4.27 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.27 |
| CHEMBL4788384 | — | — | 1 | 4.19 |
| CHEMBL4796653 | — | — | 1 | 4.19 |
| CHEMBL4751456 | — | — | 1 | 4.19 |
| CHEMBL4745678 | — | — | 1 | 4.15 |
| CHEMBL1765390 | (E)-BUTYLIDENEPHTHALIDE | — | 1 | 4.09 |
| CHEMBL1230107 | CASUARINE | — | 1 | 4.09 |
| CHEMBL457303 | BROUSSONOL E | — | 1 | 4.05 |
| CHEMBL199829 | — | — | 1 | 4.04 |
| CHEMBL371723 | — | — | 1 | 4.04 |
| CHEMBL199442 | — | — | 1 | 4.04 |
| CHEMBL382280 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4748590 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4745549 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4757703 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4800248 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL418068 | RHEIN | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL42624 | PHYSCION | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL289277 | EMODIN | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4758678 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL4783560 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL454551 | L-RADICAMINE A | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4750240 | — | IC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL13311 | CHROMONE | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL44 | GENISTEIN | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4788384 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4796653 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4751456 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4745678 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL1765390 | (E)-BUTYLIDENEPHTHALIDE | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL1230107 | CASUARINE | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL457303 | BROUSSONOL E | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL199829 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL371723 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL199442 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL382280 | — | IC50 | = | 91000.0 | nM | 4.04 |