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Assay Detail

CHEMBL4683697

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 10 mins by spectrophotometric method
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes.
Luthra T,Banothu V,Adepally U,Kumar K,M S,Chakrabarti S,Maddi SR,Sen S
Eur J Med Chem (2020) 188 : 112034 -112034
PubMed 31927314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 4.60 6.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4800248 1 6.25
CHEMBL404271 ACARBOSE 4.0 1 5.68
CHEMBL4748590 1 5.36
CHEMBL4753011 1 5.30
CHEMBL4745549 1 5.30
CHEMBL1765390 (E)-BUTYLIDENEPHTHALIDE 1 5.15
CHEMBL4799211 1 4.83
CHEMBL4751456 1 4.82
CHEMBL4796653 1 4.82
CHEMBL4788384 1 4.82
CHEMBL3407639 1 4.69
CHEMBL4750240 1 4.68
CHEMBL4740872 1 4.68
CHEMBL4743481 1 4.66
CHEMBL454551 L-RADICAMINE A 1 4.60
CHEMBL4783560 1 4.60
CHEMBL289277 EMODIN 1 4.58
CHEMBL42624 PHYSCION 1 4.58
CHEMBL40275 ALOE-EMODIN 1 4.58
CHEMBL418068 RHEIN 1 4.58
CHEMBL4758678 1 4.56
CHEMBL2260735 1 4.51
CHEMBL4757703 1 4.48
CHEMBL1230107 CASUARINE 1 4.39
CHEMBL80254 1 4.24
CHEMBL187265 1 4.21
CHEMBL197916 CUDRAXANTHONE L 1 4.21
CHEMBL478960 MACLURAXANTHONE 1 4.21
CHEMBL4745678 1 4.21
CHEMBL13311 CHROMONE 1 4.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4800248 IC50 = 560.0 nM 6.25
CHEMBL404271 ACARBOSE IC50 = 2100.0 nM 5.68
CHEMBL4748590 IC50 = 4400.0 nM 5.36
CHEMBL4753011 IC50 = 5030.0 nM 5.30
CHEMBL4745549 IC50 = 5010.0 nM 5.30
CHEMBL1765390 (E)-BUTYLIDENEPHTHALIDE IC50 = 7150.0 nM 5.15
CHEMBL4799211 IC50 = 14780.0 nM 4.83
CHEMBL4788384 IC50 = 15030.0 nM 4.82
CHEMBL4796653 IC50 = 15030.0 nM 4.82
CHEMBL4751456 IC50 = 15030.0 nM 4.82
CHEMBL3407639 IC50 = 20540.0 nM 4.69
CHEMBL4750240 IC50 = 20800.0 nM 4.68
CHEMBL4740872 IC50 = 20700.0 nM 4.68
CHEMBL4743481 IC50 = 21900.0 nM 4.66
CHEMBL4783560 IC50 = 25210.0 nM 4.60
CHEMBL454551 L-RADICAMINE A IC50 = 25210.0 nM 4.60
CHEMBL418068 RHEIN IC50 = 26430.0 nM 4.58
CHEMBL40275 ALOE-EMODIN IC50 = 26430.0 nM 4.58
CHEMBL289277 EMODIN IC50 = 26430.0 nM 4.58
CHEMBL42624 PHYSCION IC50 = 26430.0 nM 4.58
CHEMBL4758678 IC50 = 27400.0 nM 4.56
CHEMBL2260735 IC50 = 31050.0 nM 4.51
CHEMBL4757703 IC50 = 33300.0 nM 4.48
CHEMBL1230107 CASUARINE IC50 = 41120.0 nM 4.39
CHEMBL80254 IC50 = 58010.0 nM 4.24
CHEMBL4745678 IC50 = 62310.0 nM 4.21
CHEMBL478960 MACLURAXANTHONE IC50 = 62310.0 nM 4.21
CHEMBL197916 CUDRAXANTHONE L IC50 = 62310.0 nM 4.21
CHEMBL187265 IC50 = 62310.0 nM 4.21
CHEMBL13311 CHROMONE IC50 = 81030.0 nM 4.09
CHEMBL44 GENISTEIN IC50 = 81030.0 nM 4.09
CHEMBL199442 IC50 = 82670.0 nM 4.08
CHEMBL199829 IC50 = 82670.0 nM 4.08
CHEMBL371723 IC50 = 82670.0 nM 4.08
CHEMBL382280 IC50 = 82670.0 nM 4.08
CHEMBL457303 BROUSSONOL E IC50 = 85890.0 nM 4.07
CHEMBL2442255 IC50 = 91880.0 nM 4.04
CHEMBL115452 BROUSSOCHALCONE A IC50 = 101220.0 nM -