Assay Detail
Binding
CHEMBL4683838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAAH in Sprague-Dawley rat brain homogenate using arachidonoyl-ethanolamide and anandamide [ethanolamine-1-3H] as substrate pre-incubated for 10 mins followed by substrate addition and measured after 30 mins by liquid scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.84 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070196 | — | — | 1 | 10.00 |
| CHEMBL4071240 | — | — | 1 | 9.52 |
| CHEMBL4781803 | — | — | 1 | 9.15 |
| CHEMBL4742989 | — | — | 1 | 7.89 |
| CHEMBL3798032 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070196 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4071240 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4781803 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4742989 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3798032 | — | IC50 | = | 22.0 | nM | 7.66 |