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Assay Detail

CHEMBL4684121

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant Influenza A virus (A/USA:Huston/AA/1945 H1N1)) N-terminal His6-tagged PA endonuclease using 6FAM-TGGCAATATCAGCTCCACA-MGBN DNA probe as substrate by TR-FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PA endonuclease.
Liao Y,Ye Y,Li S,Zhuang Y,Chen L,Chen J,Cui Z,Huo L,Liu S,Song G
Eur J Med Chem (2020) 189 : 112048 -112048
PubMed 31954881 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 7 6.15 6.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4779680 1 6.87
CHEMBL4748299 1 6.50
CHEMBL4761767 1 6.31
CHEMBL4747090 1 6.24
CHEMBL18266 1 6.08
CHEMBL4743948 1 5.89
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 1 5.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4779680 EC50 = 134.0 nM 6.87
CHEMBL4748299 EC50 = 312.36 nM 6.50
CHEMBL4761767 EC50 = 489.39 nM 6.31
CHEMBL4747090 EC50 = 576.85 nM 6.24
CHEMBL18266 EC50 = 842.14 nM 6.08
CHEMBL4743948 EC50 = 1294.56 nM 5.89
CHEMBL297453 EPIGALOCATECHIN GALLATE EC50 = 6454.75 nM 5.19