Assay Detail
Binding
CHEMBL4684418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full-length N-terminal GST/His6-tagged CDK9 (1 to 372 residues)/His6-tagged Cyclin-T1 (1 to 726 residues) expressed in sf9 cells using (YSPTSPS)2KK peptide as substrate in presence of [gamma33P]ATP
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.11 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215205 | — | — | 1 | 6.46 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 5.75 |
| CHEMBL4783101 | — | — | 1 | - |
| CHEMBL4784840 | — | — | 1 | - |
| CHEMBL4785207 | — | — | 1 | - |
| CHEMBL4747175 | — | — | 1 | - |
| CHEMBL4747600 | — | — | 1 | - |
| CHEMBL4760748 | — | — | 1 | - |
| CHEMBL4758858 | — | — | 1 | - |
| CHEMBL4790806 | — | — | 1 | - |
| CHEMBL4798487 | — | — | 1 | - |
| CHEMBL1775075 | — | — | 1 | - |
| CHEMBL4751980 | — | — | 1 | - |
| CHEMBL4790351 | — | — | 1 | - |
| CHEMBL4762561 | — | — | 1 | - |
| CHEMBL4741899 | — | — | 1 | - |
| CHEMBL4747714 | — | — | 1 | - |
| CHEMBL4786073 | — | — | 1 | - |
| CHEMBL4741017 | — | — | 1 | - |
| CHEMBL4782119 | — | — | 1 | - |
| CHEMBL4780776 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215205 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4783101 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4784840 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4785207 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4747175 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4747600 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4760748 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4758858 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4790806 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4798487 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL1775075 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4751980 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4790351 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4762561 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4741899 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4747714 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4786073 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4741017 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4782119 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4780776 | — | IC50 | > | 12500.0 | nM | - |