Assay Detail
Functional
CHEMBL4684537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form Trypanosoma brucei brucei 427 infected in 449_Grx-roGFP2 cells assessed as cell viability after 48 hrs by propidium iodide staining based flow cytometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.68 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 7.24 |
| CHEMBL4087454 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4087454 | — | EC50 | = | 750.0 | nM | 6.12 |