Assay Detail
Binding
CHEMBL4684593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.29 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786173 | — | — | 1 | 8.92 |
| CHEMBL38874 | DAMGO | — | 1 | 8.64 |
| CHEMBL4756256 | — | — | 1 | 8.14 |
| CHEMBL1400 | O-DESMETHYL TRAMADOL | — | 1 | 7.89 |
| CHEMBL4800532 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786173 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL38874 | DAMGO | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4756256 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL1400 | O-DESMETHYL TRAMADOL | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4800532 | — | Ki | = | 14.1 | nM | 7.85 |