Assay Detail
Functional
CHEMBL4684616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of trypanosoma brucei brucei 427 assessed as reduction in parasitic growth after 72 hrs by resazurin staining based fluorescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.05 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54725 | — | — | 1 | 6.57 |
| CHEMBL4785591 | — | — | 1 | 6.25 |
| CHEMBL4760251 | — | — | 1 | 6.24 |
| CHEMBL4778279 | — | — | 1 | 6.21 |
| CHEMBL4753514 | — | — | 1 | 5.61 |
| CHEMBL4762279 | — | — | 1 | 5.43 |
| CHEMBL121445 | — | — | 1 | - |
| CHEMBL4753331 | — | — | 1 | - |
| CHEMBL158919 | — | — | 1 | - |
| CHEMBL4748094 | — | — | 1 | - |
| CHEMBL4777938 | — | — | 1 | - |
| CHEMBL4754292 | — | — | 1 | - |
| CHEMBL4797185 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54725 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4785591 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4760251 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4778279 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4753514 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4762279 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL121445 | — | IC50 | - | — | - | |
| CHEMBL4753331 | — | IC50 | - | — | - | |
| CHEMBL158919 | — | IC50 | - | — | - | |
| CHEMBL4748094 | — | IC50 | - | — | - | |
| CHEMBL4777938 | — | IC50 | - | — | - | |
| CHEMBL4754292 | — | IC50 | - | — | - | |
| CHEMBL4797185 | — | IC50 | - | — | - |