Assay Detail
Functional
CHEMBL4684787
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Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel cyclin-dependent kinase (CDK) and histone deacetylase (HDAC) dual inhibitors with potent in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.55 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761880 | — | — | 1 | 5.92 |
| CHEMBL4787723 | — | — | 1 | 5.92 |
| CHEMBL4750839 | — | — | 1 | 5.80 |
| CHEMBL4745240 | — | — | 1 | 5.80 |
| CHEMBL4741275 | — | — | 1 | 5.77 |
| CHEMBL4784610 | — | — | 1 | 5.68 |
| CHEMBL4800383 | — | — | 1 | 5.64 |
| CHEMBL4757496 | — | — | 1 | 5.58 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.57 |
| CHEMBL4798528 | — | — | 1 | 5.54 |
| CHEMBL4759239 | — | — | 1 | 5.53 |
| CHEMBL4798305 | — | — | 1 | 5.52 |
| CHEMBL4087968 | — | — | 1 | 5.39 |
| CHEMBL4782264 | — | — | 1 | 5.34 |
| CHEMBL4758936 | — | — | 1 | 5.30 |
| CHEMBL4752270 | — | — | 1 | 5.19 |
| CHEMBL518383 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761880 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4787723 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4750839 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4745240 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4741275 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4784610 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4800383 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4757496 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL4798528 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL4759239 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL4798305 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4087968 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL4782264 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL4758936 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL4752270 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL518383 | — | IC50 | = | 13380.0 | nM | 4.87 |