Assay Detail
Binding
CHEMBL4685244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by colorimetry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Thioredoxin reductase 1, cytoplasmic (CHEMBL6035) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.71 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792536 | — | — | 1 | 6.72 |
| CHEMBL4745896 | — | — | 1 | 6.23 |
| CHEMBL4459518 | — | — | 1 | 6.22 |
| CHEMBL4793784 | — | — | 1 | 5.82 |
| CHEMBL4791226 | — | — | 1 | 5.50 |
| CHEMBL4754210 | — | — | 1 | 5.47 |
| CHEMBL4739941 | — | — | 1 | 5.30 |
| CHEMBL4786625 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792536 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4745896 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4459518 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4793784 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4791226 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4754210 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL4739941 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4786625 | — | IC50 | = | 37000.0 | nM | 4.43 |