Assay Detail
Functional
CHEMBL4685245
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Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.13 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786625 | — | — | 1 | 5.23 |
| CHEMBL4745896 | — | — | 1 | 5.16 |
| CHEMBL4791226 | — | — | 1 | 5.15 |
| CHEMBL4792536 | — | — | 1 | 5.15 |
| CHEMBL4754210 | — | — | 1 | 5.15 |
| CHEMBL4793784 | — | — | 1 | 5.10 |
| CHEMBL4739941 | — | — | 1 | 5.08 |
| CHEMBL4459518 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786625 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL4745896 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL4791226 | — | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL4792536 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL4754210 | — | IC50 | = | 7070.0 | nM | 5.15 |
| CHEMBL4793784 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL4739941 | — | IC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL4459518 | — | IC50 | = | 8900.0 | nM | 5.05 |