Assay Detail
Binding
CHEMBL4685307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3 in mouse T cells assessed as reduction in IL2-stimulated cell proliferation measured after 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | T cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of 4- or 6-phenyl-pyrimidine derivatives as novel and selective Janus kinase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.68 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4746272 | — | — | 1 | 6.11 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 5.82 |
| CHEMBL4750184 | — | — | 1 | 5.68 |
| CHEMBL4780984 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4746272 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4750184 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4780984 | — | IC50 | = | 7500.0 | nM | 5.12 |